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I like the 3.5 PHB2 in general, but I am unconvinced that most of the classes would work well in AE, unless you are using the rule that AE and D&D casters are "separate but equal" (D&D casters use D&D spells and feats, AE casters use AE spells and feats, and never shall the two meet). I also feel that each of these classes is so tightly focused on a given niche that converting them to AE style casting would be doing both systems a disservice.

Beguiler is mechanically a bard without any of the thematic baggage. Imagine a rogue that gives up sneak attack and special abilities in exchange for the ability to cast like a Sorcerer with all illusion and enchantment spells known and no spells from any other schools. Now make their primary casting stat Intelligence so their skillpoints go through the roof. Then give them some class abilities that let them boost their spell DCs when casting on someone who isn't aware they are there. The beguiler is very much like the rogue, dominating social and stealth scenarios and struggling to be relevant when undead, constructs and oozes come on the scene. Ultimately, so long as they keep access to the plethora of D&D illusion and enchantment spells, the Beguiler is a very potent class...but if you converted it to AE's casting, it would become unfocused by having access to simple spells (much like the Assassin) or else become too narrow if given only AE's selection of enchantment and illusions to work with.

Dragon Shaman is an okay class mechanically, but that doesn't prevent me from thinking it is a stupid idea. Of course, I don't like the Dracha or Totem Warrior abilities that alter your physiology either, so YMMV. Essentially this is a support class with a dragon fetish. You worship a particular dragon color, which gives you various abilities including a breath weapon, auras that buff your allies, and the ability to heal and fix various conditions with a touch, all while gleefully wading into melee. Remove the color associations, tailor it to an individual dragon in your AE campaign, and it will make for an interesting lieutenant of the Squamous Horde. In fact, having each Dragon Shaman be the result of a dragon using tenebrian seeds to bind a portion of his essence to a favored servant would get rid of some of my thematic complaints with the class. (Faith goes a long way, but I draw the line at worship of a giant lizard giving you a breath weapon).

Duskblade, as Valmiras said, is pretty much covered by the Mageblade. You could change Mageblade's key casting stat to Intelligence and get pretty much the same results.

Knight is my favorite class out of PHB2, and the only one I have seen used in an AE game. My girlfriend played a Knight from level four to ten over the course of a short campaign, and aside from the limited bonus feat list, had no complaints. Having played both, she prefers the Knight to the Champion (which she played all the way to 20th level in our first AE campaign). The main thing which makes or breaks the Knight for most people is the Knight's Challenge ability which forms the cornerstone of the class. Essentially the Knight controls the battlefield with extraordinary mind-affecting challenges, much like a "Tank" class in an MMORPG. By shouting challenges to her foes, she can scare low-level minions into fleeing, force worthy opponents to face them in single combat, and generally prevent anything from getting past them to attack the squishy casters in the back. They also have a code of conduct, but unlike the paladin or oathsworn, they cannot lose their knighthood by breaking it, merely expending a use of their knight's challenge for the day whenever they break it. They are definately a little bit more "magical" than your standard fighter, but they are far more mundane in feel than the Champion, and lack the religious overtones of the Paladin. My only issue with the Knight is that they are infuriating as NPC villains, much like evil enchanters who take control of the character out of the player's hands.

Robert "Knight Works, The Others Are Iffy IMHO" Ranting